Assignment Topic
3) Feature a Blood
In Module 9, we review the blood, its carrying capacity for gasses, and the exchange of these gasses at the tissue and the lungs. We discussed several factors related to blood pressure and ventilation, including their modulation. This week, well take a deeper look into one of these areas.
Prompt: Choose one of the following
1) Carbonic Anhydrase
Its the bicarbonate splitting/creating enzyme that keeps popping up throughout our physiology course.
Describe the location and roles of carbonic anhydrase throughout the body
Detail carbonic anhydrase/bicarbonates role in transporting CO2 as carbaminohemoglobin
Describe how the hydrogen ion buffering role of bicarbonate and how it leads to the development of nonmetabolic CO2 during anaerobic stressors like high intensity exercise, leading to an alinear rise in minute ventilation.
2) The Ocyhemoglobin Dissociation Curve
Before you begin namedropping this polysyllabic term to impress others, begin by explaining its dynamics and why understanding it is critical to grasping cardiopulmonary physiology
Describe the axes of the oxyhemoglobin dissociation curve, where on the curve we typically load and offload hemoglobin, and how the curve shifts due to the presence of certain ions and conditions
Briefly describe a condition in which oxygen saturation may be compromised, and strategies employed to restore oxygen saturation
Does oxygen saturation decline during a graded exercise test?
3) Feature a Blood Cell
In this video, youll tell the story of either an Erythrocyte, Neutrophil, B-Lymphocyte, T-Lymphocyte, Monocyte, Eosinophil, or Basophil; describing:
1) Pathway and triggers for production
2) Lifecycle of the cell, where it is stored, and circumstances in which it is most active or abundant
3) Measurement techniques and dangers/implications of varying levels of the cell (high or low)
4) Process of degradation of the cell
4) Pharmacotherapy of Blood Pressure: The Renin-Angiotensin Aldosterone System
Describe the pathway of 2 of the following classes of blood pressure medications:
Angiotensin Receptor Blockers
Ace Inhibitors
To do so, youll need to describe
1) The Renin-Angiotensin Aldosterone System (RAAS), a multi-organ system (liver, lungs, kidney) which leads to angiotensin II and aldosterone production which increases blood pressure.
2) Detail pathways of pharmaceutical approaches of ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)
3) Describe potential side effects and circumstances in which these drugs are, and are not prescribed.
Instructions:
1. Research your topic using the resources provided as well as valid external resources such as research papers.
2. Design your 5 minute video. This may be a slide presentation, a recording of you drawing out your pathway on a whiteboard, an explainer using complete anatomy, or a combination of the three.
3. Record yourself. To do so, you may use a screen capture application such as Snipit or Screenshot (on Mac). As you do, make sure the produced file is a video file (i.e. .mp4)
4. Publish to a hosting site. Videos are to be published as Unlisted, not Private or Public.
5. Post your video link. The link should follow a 1-line title of your chosen topic. If outside sources such as research papers or textbooks were used, please include citations in APA format in your submission below the link to your video. Below is an example of a submission using a topic from Module 7 topic. You will not be able to view your classmates work until your work is submitted.
Cardiac Action Potentials and the Autonomic Nervous System
YouTube.com/demo
Faber, G. M., & Rudy, Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal, 78(5), 23922404. https://doi.org/10.1016/S0006-3495(00)76783-X
